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Autologous cancer vaccine treatment

What is autologous cancer vaccine therapy?

This is a type of immunotherapy that aims to induce a specific immune response against cancer in the body by administering a vaccine made from the patient's own cancer tissue, thereby achieving an anti-tumor effect.
This treatment is being carried out under technical support from CellMedicine.

Sun Clinic Breast Care/Immunocare Autologous Cancer Vaccine Treatment

Mechanism of action of autologous cancer vaccine therapy

Administered cancer vaccines are thought to exert antitumor effects in the following ways:

  1. Cancer vaccine administered intradermally

  2. Antigen-presenting cells such as dendritic cells and macrophages present in the skin consume cancer vaccines

  3. Antigen-presenting cells that have consumed the cancer vaccine migrate to nearby lymph nodes

  4. Antigen presentation in the migrated lymph nodes

  5. Proliferation and activation of specific CTLs (cytotoxic T lymphocytes) that can respond to the presented antigens

  6. The proliferated and activated specific CTLs migrate to the cancer site and kill the cancer cells.

Treatment flow, treatment period, and number of treatments

Step 1: Interview, medical examination

Step 2: Provide 2g of tumor tissue (formalin-fixed tissue or paraffin-embedded block)

Step 3: Autologous cancer vaccine production (outsourced, approximately 5 days)

Step 4: Vaccinate according to the following schedule:

Sun Clinic Breast Care/Immunocare Autologous Cancer Vaccine Treatment

Fees (private medical treatment)

1,650,000 yen (tax included) to 3,300,000 yen (tax included)

Side effects of autologous cancer vaccines

Common side effects include local redness, swelling, induration, and fever, all of which are temporary.
Anaphylactic shock may occur as a rare serious side effect, however, no cases of anaphylactic shock have been reported to date.

Regarding elective medical treatment using unapproved drugs, etc.

● Clear indication that the drug is an unapproved drug, etc., and clear indication of the acquisition route, etc.

Autologous cancer vaccines have not been approved under the Pharmaceutical and Medical Device Act. In Japan, unapproved drugs and medical devices can be used at the doctor's own risk.

 

● Availability of domestically approved drugs, etc.

Currently, there are no other drugs approved in Japan that have the same properties as those used in this treatment.

 

● Information on safety in other countries

Currently, there is no information regarding safety in other countries.

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