SOT antisense therapy
What is SOT antisense therapy?
SOT (Supportive Oligonucleotide Therapy) antisense therapy is a treatment in which an antisense drug that is thought to be effective in suppressing CTCs is created based on the results of gene expression analysis of CTCs obtained from cancer stem cell testing , and is injected once or twice.The antisense drug works by inhibiting the synthesis of proteins required by cancer cells, suppressing their proliferation, or inducing apoptosis in cancer cells, which is expected to have an antitumor effect.
Mechanism of action of SOT antisense therapy
Cells contain genes (DNA), and proteins are synthesized from DNA as needed. DNA consists of two strands: the strand that carries genetic information is called the sense strand, and the other strand that does not carry genetic information is called the antisense strand. Protein synthesis involves copying the information on the sense strand of DNA into RNA, which is then stripped of unnecessary parts to create mRNA, which is then delivered to the ribosome for synthesis.
On the other hand, unlike viruses and other microorganisms, human cells have RNA that is made up of a single strand. Since double-stranded RNA does not exist, if double-stranded RNA is present, it will be quickly degraded by enzymes. SOT antisense therapy takes advantage of this mechanism. Specifically, by administering RNA (antisense) that can bind to the abnormal mRNA produced by cancer cells, double-stranded RNA is produced, which is then degraded by enzymes, inhibiting the synthesis of necessary proteins.
Treatment overview
This treatment is an elective medical treatment.
SOT antisense therapy flow
Step 1: Interview, medical examination
Step 2: Cancer stem cell test (Oncotrace RGCC + Onconomics Plus)
Step 3: Antisense drug production is outsourced (approximately 4-6 weeks)
Step 4: Administration (approximately 1 hour)
Treatment period and number of times
The treatment will vary depending on the patient's condition and symptoms, so we will make a decision after the patient has undergone an examination and tests.
Cost (free medical treatment)
770,000 yen to 1,540,000 yen
Risks and side effects
To date, no serious side effects have been reported with this treatment.
Mild side effects such as headache or rash may occur in rare cases.
Regarding elective medical treatment using unapproved drugs, etc.
● Unapproved drugs, etc.
The unapproved drugs used in this treatment have not yet been approved under the Pharmaceutical and Medical Device Act. In Japan, unapproved drugs and medical devices can be used at the doctor's own risk.
● Acquisition route etc.
Available through domestic distributors.
● Availability of domestically approved drugs, etc.
There are no other domestically approved drugs that have the same properties as those used in this treatment.
● Information on safety in other countries
Currently, there is no information regarding safety in other countries.